Strategy: Checkerboard pattern
If obsidian is expensive, and you want the most efficient way to defend your base with it, the chequerboard pattern strategy might be suitable for you.
Example design of Obsidian wall.
X | X | X | X | ||||
X | X | X | X | ||||
X | X | X | X | ||||
X | X | X | X |
X = obsidian
Open = Stone brick e.g. or another block.